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|Title:||The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency||Authors:||Cao, Haoqing
Chew, Sing Yian
|Keywords:||DRNTU::Engineering::Chemical engineering::Biochemical engineering||Issue Date:||2012||Source:||Cao, H., Marcy, G., Goh, E. L. K., Wang, F., Wang, J., & Chew, S. Y. (2012). The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency. Macromolecular bioscience, 12(5), 666-674.||Series/Report no.:||Macromolecular bioscience||Abstract:||Astrocyte-nanofiber interactions are studied by culturing primary rat cortical astrocytes on poly[caprolactone-co-(ethyl ethylene phosphate)] electrospun nanofibers and solvent-cast films (two-dimensional control). The results indicate that nanofiber topography significantly suppresses astrocyte proliferation and enhances apoptosis, without altering cellular activation as compared to films. Moreover, nanofiber topography enhances gene-silencing efficiency in astrocytes. The results suggest that nanofibers may serve as potential substrates for nerve regeneration by suppressing astrocyte growth and may further facilitate the use of gene-silencing to enhance CNS regeneration.||URI:||https://hdl.handle.net/10356/95802
|ISSN:||1616-5195||DOI:||10.1002/mabi.201100436||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SCBE Journal Articles|
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