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Title: The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency
Authors: Cao, Haoqing
Marcy, Guillaume
Goh, Eyleen
Wang, Feng
Wang, Jun
Chew, Sing Yian
Keywords: DRNTU::Engineering::Chemical engineering::Biochemical engineering
Issue Date: 2012
Source: Cao, H., Marcy, G., Goh, E. L. K., Wang, F., Wang, J., & Chew, S. Y. (2012). The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency. Macromolecular bioscience, 12(5), 666-674.
Series/Report no.: Macromolecular bioscience
Abstract: Astrocyte-nanofiber interactions are studied by culturing primary rat cortical astrocytes on poly[caprolactone-co-(ethyl ethylene phosphate)] electrospun nanofibers and solvent-cast films (two-dimensional control). The results indicate that nanofiber topography significantly suppresses astrocyte proliferation and enhances apoptosis, without altering cellular activation as compared to films. Moreover, nanofiber topography enhances gene-silencing efficiency in astrocytes. The results suggest that nanofibers may serve as potential substrates for nerve regeneration by suppressing astrocyte growth and may further facilitate the use of gene-silencing to enhance CNS regeneration.
ISSN: 1616-5195
DOI: 10.1002/mabi.201100436
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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