Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/96377
Title: Argon-plasma-induced ultrathin thermal grafting of thermoresponsive pNIPAm coating for contractile patterned human SMC sheet engineering
Authors: Rayatpisheh, Shahrzad
Li, Peng
Chan-Park, Mary B.
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2012
Source: Rayatpisheh, S., Li, P., & Chan-Park, M. B. (2012). Argon-plasma-induced ultrathin thermal grafting of thermoresponsive pNIPAm coating for contractile patterned human SMC sheet engineering. Macromolecular bioscience, 12(7), 937-945.
Series/Report no.: Macromolecular bioscience
Abstract: A new method for ultrathin grafting of pNIPAm on PDMS surfaces is introduced that employs plasma activation of the surface followed by thermal polymerization. This method is optimized for human primary SMC attachment and subsequent intact cell sheet detachment by lowering the temperature. The contractile gene expression of the cells showed that the contractile phenotype of the SMCs which is induced by aligning the cells through micropatterning is more preserved after thermoresponsive cell sheet detachment in contrast with enzymatic detachment. Given its simplicity and low cost, this thermoresponsive grafting method can be utilized for engineering patterned cell sheets for future bottom-up tissue engineering techniques.
URI: https://hdl.handle.net/10356/96377
http://hdl.handle.net/10220/17320
ISSN: 1616-5195
DOI: 10.1002/mabi.201100477
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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