Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/96548
Title: Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
Authors: Wang, Zhaohui
Hu, Hongliang
Zheng, Jie
Li, Biaoru
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2011
Source: Wang, Z., Hu, H., Zheng, J., & Li, B. (2011). Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood - study on toxicogenomics and prevention targeting. 2011 IEEE 11th International Conference on Bioinformatics and Bioengineering, pp72-77.
Abstract: The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.
URI: https://hdl.handle.net/10356/96548
http://hdl.handle.net/10220/17351
DOI: http://dx.doi.org/10.1109/BIBE.2011.18
Rights: © 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [http://dx.doi.org/10.1109/BIBE.2011.18]
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
Appears in Collections:SCSE Conference Papers

Files in This Item:
File Description SizeFormat 
Zheng_BIBE_2011_LiverCancer.pdf613.81 kBAdobe PDFThumbnail
View/Open

Page view(s)

348
checked on Dec 24, 2019

Download(s)

183
checked on Dec 24, 2019

Google ScholarTM

Check

Altmetric

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.