Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/99289
Title: The in vivo biofilm
Authors: Jensen, Peter Østrup
Høiby, Niels
Bjarnsholt, Thomas
Alhede, Maria
Alhede, Morten
Eickhardt-Sørensen, Steffen R.
Moser, Claus
Kühl, Michael
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2013
Source: Bjarnsholt, T., Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, C., Kühl, M., et al. (2013). The in vivo biofilm. Trends in Microbiology, 21(9), 466-474.
Series/Report no.: Trends in microbiology
Abstract: Bacteria can grow and proliferate either as single, independent cells or organized in aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm within the human host, the infection often becomes very resistant to treatment and can develop into a chronic state. Biofilms have been studied for decades using various in vitro models, but it remains debatable whether such in vitro biofilms actually resemble in vivo biofilms in chronic infections. In vivo biofilms share several structural characteristics that differ from most in vitro biofilms. Additionally, the in vivo experimental time span and presence of host defenses differ from chronic infections and the chemical microenvironment of both in vivo and in vitro biofilms is seldom taken into account. In this review, we discuss why the current in vitro models of biofilms might be limited for describing infectious biofilms, and we suggest new strategies for improving this discrepancy.
URI: https://hdl.handle.net/10356/99289
http://hdl.handle.net/10220/17367
ISSN: 0966-842X
DOI: http://dx.doi.org/10.1016/j.tim.2013.06.002
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