Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/99329
Title: Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters
Authors: Yan, Lin
Han, Zhiqiang
Zhu, Bo
Yang, Caiyun
Tan, Choon-Hong
Jiang, Zhiyong
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2013
Source: Yan, L., Han, Z., Zhu, B., Yang, C., Tan, C.-H., & Jiang, Z. (2013). Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters. Beilstein journal of organic chemistry, 9, 1853-1857.
Series/Report no.: Beilstein journal of organic chemistry
Abstract: In the presence of a commercially available Cinchona alkaloid as catalyst, the asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates, with α-fluoro-β-keto esters as nucleophiles, have been successfully developed. A series of important fluorinated adducts, with chiral quaternary carbon centres containing a fluorine atom, was achieved in good yields (up to 93%), with good to excellent enantioselectivities (up to 96% ee) and moderate diastereoselectivities (up to 4:1 dr).
URI: https://hdl.handle.net/10356/99329
http://hdl.handle.net/10220/17425
DOI: http://dx.doi.org/10.3762/bjoc.9.216
Rights: © 2013 Yan et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions:(http://www.beilstein-journals.org/bjoc)
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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