Bicyclic guanidinium-catalyzed enantioselective phase-transfer alkylation : direct access to pyrroloindolines and furoindolines
Author
Chen, Wenchao
Yang, Wenguo
Yan, Lin
Tan, Choon-Hong
Jiang, Zhiyong
Date of Issue
2013School
School of Physical and Mathematical Sciences
Abstract
Highly enantioselective phase-transfer alkylation of 3-substituted-2-oxindoles with activated bromomethanes is disclosed with a broad substrate scope by using bicyclic guanidinium as a catalyst and a Lewis acid as the co-catalyst. The alkylation adducts are versatile intermediates to accomplish the syntheses of pyrroloindolines and furoindolines.
Subject
DRNTU::Science::Chemistry
Type
Journal Article
Series/Journal Title
Chemical communications
Collections
http://dx.doi.org/10.1039/c3cc46111d
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