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      Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity

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      Specific Surface Area of Titanium Dioxide (TiO2) Particles Influences Cyto- and Photo- Toxicity.pdf (996.7Kb)
      Author
      Xiong, Sijing
      Tang, Yuxin
      Ng, Huiyun Sheena
      Zhao, Xinxin
      Jiang, Zhelong
      Chen, Zhong
      Ng, Kee Woei
      Loo, Say Chye Joachim
      Date of Issue
      2013
      School
      School of Materials Science and Engineering
      Version
      Accepted version
      Abstract
      The aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO2) particles could influence both cytotoxicity and phototoxicity. TiO2 particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence and presence of UV light. From the results, TiO2 particles with larger specific surface area were found to induce higher cyto- (UV absent) and photo-toxicity (UV activated) to cells after 24 h incubation. The observed cytotoxicity from TiO2 particles with larger surface area could be explained from their interactions with biomolecules. Upon photoactivation, a larger number of hydroxyl radicals were detected from TiO2 particles with larger surface area, again suggesting a surface area dependent phototoxic effect. On the other hand, pre-adsorbing TiO2 particles with extracellular proteins were found to decrease toxicity effects.
      Subject
      DRNTU::Engineering::Materials
      Type
      Journal Article
      Series/Journal Title
      Toxicology
      Rights
      © 2013 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Toxicology, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.tox.2012.12.015].
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      • MSE Journal Articles
      http://dx.doi.org/10.1016/j.tox.2012.12.015
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