dc.contributor.authorXiong, Sijing
dc.contributor.authorTang, Yuxin
dc.contributor.authorNg, Huiyun Sheena
dc.contributor.authorZhao, Xinxin
dc.contributor.authorJiang, Zhelong
dc.contributor.authorChen, Zhong
dc.contributor.authorNg, Kee Woei
dc.contributor.authorLoo, Say Chye Joachim
dc.identifier.citationXiong, S., Tang, Y., Ng, H. S., Zhao, X., Jiang, Z., Chen, Z., Ng, K. W., & Loo, S. C. J. (2013). Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity. Toxicology, 304(8), 132-140.en_US
dc.description.abstractThe aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO2) particles could influence both cytotoxicity and phototoxicity. TiO2 particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence and presence of UV light. From the results, TiO2 particles with larger specific surface area were found to induce higher cyto- (UV absent) and photo-toxicity (UV activated) to cells after 24 h incubation. The observed cytotoxicity from TiO2 particles with larger surface area could be explained from their interactions with biomolecules. Upon photoactivation, a larger number of hydroxyl radicals were detected from TiO2 particles with larger surface area, again suggesting a surface area dependent phototoxic effect. On the other hand, pre-adsorbing TiO2 particles with extracellular proteins were found to decrease toxicity effects.en_US
dc.rights© 2013 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Toxicology, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.tox.2012.12.015].en_US
dc.titleSpecific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicityen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionAccepted versionen_US

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