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|Title:||Cobalt-catalyzed ortho alkylation of aromatic imines with primary and secondary alkyl halides||Authors:||Gao, Ke
|Keywords:||DRNTU::Science::Chemistry::Organic chemistry||Issue Date:||2013||Source:||Gao, K., & Yoshikai, N. (2013). Cobalt-catalyzed ortho alkylation of aromatic imines with primary and secondary alkyl halides. Journal of the American chemical society, 135(25), 9279-9282.||Series/Report no.:||Journal of the American chemical society||Abstract:||We report here cobalt–N-heterocyclic carbene catalytic systems for the ortho alkylation of aromatic imines with alkyl chlorides and bromides, which allows the introduction of a variety of primary and secondary alkyl groups at room temperature. The stereochemical outcomes of the reaction of secondary alkyl halides suggest that the present reaction involves single-electron transfer from a cobalt species to the alkyl halide to generate the corresponding alkyl radical. A cycloalkylated product obtained by this method can be transformed into unique spirocycles through manipulation of the directing and cycloalkyl groups.||URI:||https://hdl.handle.net/10356/99605
|DOI:||http://dx.doi.org/10.1021/ja403759x||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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