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Title: Cobalt-catalyzed ortho-alkenylation of aromatic aldimines via chelation-assisted C–H bond activation
Authors: Yamakawa, Takeshi
Yoshikai, Naohiko
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2013
Source: Yamakawa, T., & Yoshikai, N. (2013). Cobalt-catalyzed ortho-alkenylation of aromatic aldimines via chelation-assisted C–H bond activation. Tetrahedron, 69(22), 4459-4465
Series/Report no.: Tetrahedron
Abstract: An ortho-alkenylation reaction of an aromatic aldimine with an internal alkyne is efficiently promoted by a cobalt catalyst generated from CoBr2, triarylphosphine, and iPrMgBr. The reaction takes place under mild room-temperature conditions to afford, upon acidic hydrolysis, a variety of ortho-alkenylated aromatic aldehydes in moderate to excellent yields. The neighboring formyl and alkenyl groups in the product can be utilized as synthetic handles for the facile construction of indene and naphthalene carbocycles.
ISSN: 0040-4020
DOI: 10.1016/j.tet.2013.02.092
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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