cis-Enals in N-heterocyclic carbene-catalyzed reactions : distinct stereoselectivity and reactivity
Chi, Robin Yonggui
Date of Issue2013
School of Physical and Mathematical Sciences
The first successful generation of cis-homoenolate equivalents from cis-enals under the catalysis of N-heterocyclic carbenes (NHCs) has been realized. The cis-homoenolate intermediates undergo effective reactions with α,β-unsaturated imines to afford chiral cyclic ketone products. Compared to the trans-enals, cis-enals show different stereoselectivities and new reactivity patterns.
Physical and Mathematical Sciences