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Title: Synthesis of pyridines by carbenoid-mediated ring opening of 2H-azirines
Authors: Singh, Alok
Xu, Xianxiu
Park, Cheol-Min
Loy, Nicole S. Y.
Keywords: Chemistry and Biological Chemistry
Issue Date: 2013
Source: Loy, N. S. Y., Singh, A., Xu, X., & Park, C.-M. (2013). Synthesis of Pyridines by Carbenoid-Mediated Ring Opening of 2 H -Azirines . Angewandte Chemie International Edition, 52(8), 2212-2216.
Series/Report no.: Angewandte chemie international edition
Abstract: Roaming the range: The title reaction tolerates a wide range of substituents on the resulting pyridine ring using mild reaction conditions (see scheme; esp=α,α,α′,α′-tetramethyl-1,3-benzenedipropionic acid). The formation of the key intermediate is catalyst-controlled, and subsequent cyclization and oxidation affords pyridines in excellent yields. The method has been used for the efficient synthesis of polyarylpyridines.
ISSN: 1433-7851
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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