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      Ternary copper(ii)-polypyridyl enantiomers: aldol-type condensation, characterization, DNA-binding recognition, BSA-binding and anticancer property

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      Author
      Ng, Chew-Hee
      Wang, Wai-San
      Chong, Kok-Vei
      Win, Yip-Foo
      Neo, Kian-Eang
      Lee, Hong-Boon
      San, Swee-Lan
      Raja Abd. Rahman, Raja Noor Zaliha
      Leong, Weng Kee
      Date of Issue
      2013
      School
      School of Physical and Mathematical Sciences
      Abstract
      Chiral enantiomers [Cu(phen)(L-threo)(H2O)]NO31 and [Cu(phen)(D-threo)(H2O)]NO32 (threo = threoninate) underwent aldol-type condensation with formaldehyde, with retention of chirality, to yield their respective enantiomeric ternary copper(II) complexes, viz.L- and D-[Cu(phen)(5MeOCA)(H2O)]NO3·xH2O (3 and 4; phen = 1,10-phenanthroline; 5MeOCA = 5-methyloxazolidine-4-carboxylate; x = 0–3) respectively. These chiral complexes were characterized by FTIR, elemental analysis, circular dichroism, UV-Visible spectroscopy, fluorescence spectroscopy (FL), molar conductivity measurement, ESI-MS and X-ray crystallography. Analysis of restriction enzyme inhibition by these four complexes revealed modulation of DNA binding selectivity by the type of ligand, ligand modification and chirality. Their interaction with bovine serum albumin was investigated by FL and electronic spectroscopy. With the aid of the crystal structure of BSA, spectroscopic evidence suggested their binding at the cavity containing Trp134 with numerous Tyr residues in subdomain IA. The products were more antiproliferative than cisplatin against cancer cell lines HK-1, MCF-7, HCT116, HSC-2 and C666-1 except HL-60, and were selective towards nasopharyngeal cancer HK-1 cells over normal NP69 cells of the same organ type.
      Subject
      Chemistry and Biological Chemistry
      Type
      Journal Article
      Series/Journal Title
      Dalton transactions
      Collections
      • SPMS Journal Articles
      http://dx.doi.org/10.1039/c3dt50884f
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