Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/99766
Title: Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa
Authors: Mohanty, Anee
Kathawala, Mustafa Hussain
Zhang, Jianhua
Yang, Liang
Kjelleberg, Staffan
Cao, Bin
Chen, William Wei Ning
Loo, Joachim Say Chye
Keywords: DRNTU::Engineering::Chemical engineering::Biotechnology
Issue Date: 2013
Source: Mohanty, A., Kathawala, M. H., Zhang, J., Chen, W. N. W., Loo, S. C. J., Kjelleberg, S., et al. (2013). Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa . Biotechnology and Bioengineering, 111(5), 858–865.
Series/Report no.: Biotechnology and bioengineering
Abstract: While antibiotic resistance in bacteria is rapidly increasing, the development of new antibiotics has decreased in recent years. Antivirulence drugs disarming rather than killing pathogens have been proposed to alleviate the problem of resistance inherent to existing biocidal antibiotics. Here, we report a nontoxic biogenic nanomaterial as a novel antivirulence agent to combat bacterial infections caused by Pseudomonas aeruginosa. We synthesized, in an environmentally benign fashion, tellurium nanorods (TeNRs) using the metal-reducing bacterium Shewanella oneidensis, and found that the biogenic TeNRs could effectively inhibit the production of pyoverdine, one of the most important virulence factors in P. aeruginosa. Our results suggest that amyloids and extracellular polysaccharides Pel and Psl are not involved in the interactions between P. aeruginosa and the biogenic TeNRs, while flagellar movement plays an important role in the cell-TeNRs interaction. We further showed that the TeNRs (up to 100 µg/ml) did not exhibit cytotoxicity to human bronchial epithelial cells and murine macrophages. Thus, biogenic TeNRs hold promise as a novel antivirulence agent against P. aeruginosa.
URI: https://hdl.handle.net/10356/99766
http://hdl.handle.net/10220/17820
ISSN: 0006-3592
DOI: 10.1002/bit.25147
Rights: © 2013 Wiley Periodicals, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Biotechnology and bioengineering, Wiley Periodicals, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/bit.25147].
Fulltext Permission: open
Fulltext Availability: With Fulltext
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