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      Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe

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      Author
      Yuen, Clement
      Liu, Quan
      Date of Issue
      2013
      School
      School of Chemical and Biomedical Engineering
      Abstract
      We propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 μm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in the Ag-coated microneedle-based probe is found to be the key to the effective detection of analytes buried inside the aforesaid phantom. Glucose concentrations ranging from 5 to 150 mM inside phantoms can be estimated with a root mean square error (RMSE) of 3.3 mM. This work shows the potential of using microneedles for simple in vivo intradermal SERS measurements of analytes with clinical relevance.
      Subject
      DRNTU::Science::Chemistry::Biochemistry
      Type
      Journal Article
      Series/Journal Title
      Journal of biophotonics
      Rights
      © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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      • SCBE Journal Articles
      http://dx.doi.org/10.1002/jbio.201300006
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