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https://hdl.handle.net/10356/96608
Title: | Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe | Authors: | Yuen, Clement Liu, Quan |
Keywords: | DRNTU::Science::Chemistry::Biochemistry | Issue Date: | 2013 | Source: | Yuen, C., & Liu, Q. (2013). Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe. Journal of biophotonics, 7(9), 683-689. | Series/Report no.: | Journal of biophotonics | Abstract: | We propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 μm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in the Ag-coated microneedle-based probe is found to be the key to the effective detection of analytes buried inside the aforesaid phantom. Glucose concentrations ranging from 5 to 150 mM inside phantoms can be estimated with a root mean square error (RMSE) of 3.3 mM. This work shows the potential of using microneedles for simple in vivo intradermal SERS measurements of analytes with clinical relevance. | URI: | https://hdl.handle.net/10356/96608 http://hdl.handle.net/10220/18057 |
ISSN: | 1864-063X | DOI: | 10.1002/jbio.201300006 | Schools: | School of Chemical and Biomedical Engineering | Rights: | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SCBE Journal Articles |
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