Designing drug-loaded multi-layered polymeric microparticles
Lee, Wei Li
Loo, Say Chye Joachim
Date of Issue2011
School of Materials Science and Engineering
This work reports how novel multi-layered (from double-layered to quadruple-layered) microparticles comprising immiscible polymers can be fabricated through a simple, economical, reliable and versatile one-step solvent evaporation method. These multi-layered microparticles would be excellent candidates to overcome problems inherent in single-layered microparticles for drug delivery. Particle morphologies, layer configurations, and drug distribution were determined by scanning electron microscopy and Raman mapping. Key process parameters achieving the formation of the multi-layered structure were identified. Encapsulation of multiple drugs and layer localization of these drugs within these multi-layered microparticles have also shown to be possible, which were driven by drug-polymer affinity. This one-step fabrication technique can therefore be used for tailoring particle designs, thus facilitating the development of multiparticulate drug delivery devices.
Journal of materials science : materials in medicine
© 2011 Springer Science+Business Media, LLC. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of materials science : materials in medicine, Springer Science+Business Media, LLC. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1007/s10856-011-4508-z].