dc.contributor.authorYang, Peng
dc.contributor.authorWu, Min
dc.contributor.authorKwoh, Chee Keong
dc.contributor.authorKhil, Pavel P.
dc.contributor.authorPrzytycka, Teresa M.
dc.contributor.authorR. Daniel Camerini-Otero
dc.contributor.authorZheng, Jie
dc.date.accessioned2013-12-09T02:48:51Z
dc.date.available2013-12-09T02:48:51Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.citationYang, P., Wu, M., Kwoh, C. K., Khil, P. P., Przytycka, T. M., R. Daniel C. O., & Zheng, J. (2012). Predicting DNA sequence motifs of recombination hotspots by integrative visualization and analysis. International Symposium on Integrative Bioinformatics 2012.
dc.identifier.urihttp://hdl.handle.net/10220/18173
dc.description.abstractMeiotic recombination hotspots play important roles in life sciences, but the regulatory mechanism remain unclear. To predict DNA sequence motifs that regulate recombination hotspots, we designed an open source software tool called “LDsplit” that detects SNPs (single nucleotide polymorphisms) associated with meiotic recombination hotspots. The association is measured by the difference of historical recombination rates at a hotspot between two sub-populations with different alleles of a candidate SNP. Providing userfriendly graphic interface and integrative visualization, LDsplit provides insight into the relation of recombination hotspots with proximal DNA sequence patterns.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.rightsLDsplit is an open source Java program.en_US
dc.subjectDRNTU::Engineering::Computer science and engineering::Software
dc.titlePredicting DNA sequence motifs of recombination hotspots by integrative visualization and analysisen_US
dc.typeConference Paper
dc.contributor.conferenceInternational Symposium on Integrative Bioinformatics (2012 : Hangzhou, China)en_US
dc.contributor.schoolSchool of Computer Engineeringen_US
dc.description.versionAccepted versionen_US


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