dc.contributor.authorWu, Min
dc.contributor.authorKwoh, Chee Keong
dc.contributor.authorPrzytycka, Teresa M.
dc.contributor.authorLi, Jing
dc.contributor.authorZheng, Jie
dc.date.accessioned2013-12-10T01:55:53Z
dc.date.available2013-12-10T01:55:53Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.citationWu, M., Kwoh, C. K., Przytycka, T. M., Li, J.,& Zheng, J. (2012). Epigenetic functions enriched in transcription factors binding to mouse recombination hotspots. Proteome science, 10(Suppl 1), S11.en_US
dc.identifier.issn1477-5956en_US
dc.identifier.urihttp://hdl.handle.net/10220/18190
dc.description.abstractThe regulatory mechanism of recombination is a fundamental problem in genomics, with wide applications in genome-wide association studies, birth-defect diseases, molecular evolution, cancer research, etc. In mammalian genomes, recombination events cluster into short genomic regions called “recombination hotspots”. Recently, a 13-mer motif enriched in hotspots is identified as a candidate cis-regulatory element of human recombination hotspots; moreover, a zinc finger protein, PRDM9, binds to this motif and is associated with variation of recombination phenotype in human and mouse genomes, thus is a trans-acting regulator of recombination hotspots. However, this pair of cis and trans-regulators covers only a fraction of hotspots, thus other regulators of recombination hotspots remain to be discovered. In this paper, we propose an approach to predicting additional trans-regulators from DNA-binding proteins by comparing their enrichment of binding sites in hotspots. Applying this approach on newly mapped mouse hotspots genome-wide, we confirmed that PRDM9 is a major transregulator of hotspots. In addition, a list of top candidate trans-regulators of mouse hotspots is reported. Using GO analysis we observed that the top genes are enriched with function of histone modification, highlighting the epigenetic regulatory mechanisms of recombination hotspots.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofseriesProteome scienceen_US
dc.rights© 2012 Wu et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectDRNTU::Engineering::Computer science and engineering
dc.titleEpigenetic functions enriched in transcription factors binding to mouse recombination hotspotsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Computer Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1186/1477-5956-10-S1-S11
dc.description.versionPublished versionen_US


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