Bicyclic-guanidine-catalyzed asymmetric Michael addition of 3-substituted oxindoles to 2-cyclopentenone
Author
Yang, Caiyun
Chen, Wenchao
Yang, Wenguo
Zhu, Bo
Yan, Lin
Tan, Choon-Hong
Jiang, Zhiyong
Date of Issue
2013School
School of Physical and Mathematical Sciences
Abstract
Taking the Michael: The first highly enantio- and diastereoselective Michael addition of various 3-benzyl-substituted oxindoles to 2-cyclopentenone has been developed. A variety of 3,3-disubstituted oxindoles as Michael adducts were obtained in 69–99 % yield with 73–98 % ee and 9:1 to >20:1 d.r.
Subject
DRNTU::Science::Chemistry::Physical chemistry
Type
Journal Article
Series/Journal Title
Chemistry - an Asian journal
Rights
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Collections
http://dx.doi.org/10.1002/asia.201301011
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