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https://hdl.handle.net/10356/102450
Title: | Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos | Authors: | Zhao, Xinxin Ong, Kimberly J. Ede, James D. Stafford, James L. Ng, Kee Woei Goss, Greg G. Loo, Joachim Say Chye |
Keywords: | DRNTU::Engineering::Materials | Issue Date: | 2013 | Source: | Zhao, X., Ong, K. J., Ede, J. D., Stafford, J. L., Ng, K. W., Goss, G. G., et al. (2013). Evaluating the Toxicity of Hydroxyapatite Nanoparticles in Catfish Cells and Zebrafish Embryos. Small, 9(9-10), 1734-1741. | Series/Report no.: | Small | Abstract: | The toxicity of needle-(nHA-ND) and rod-shaped (nHA-RD) hydroxyapatite (HA) nanoparticles is evaluated in vitro on catfish B-cells (3B11) and catfish T-cells (28s.3) and in vivo on zebrafish embryos to determine if biological effects are similar to the effects seen in mammalian in vitro systems. Neither nHA-ND nor nHA-RD affect cell viability at concentrations of 10 to 300 μg mL−1. However, 30 μg mL−1 needle-shaped nHA lower metabolic activity of the cells. Axial deformations are seen in zebrafish exposed to 300 μg mL−1 needle shaped nHA after 120 h. For the first time, nHA is reported to cause zebrafish hatching delay. The lowest concentration (3 μg mL−1) of both types of nHA cause the highest hatching inhibition and needle-shaped nHA exposed zebrafish exhibit the lowest hatch at 72 h post fertilization. | URI: | https://hdl.handle.net/10356/102450 http://hdl.handle.net/10220/18981 |
ISSN: | 1613-6810 | DOI: | 10.1002/smll.201200639 | Schools: | School of Materials Science & Engineering | Rights: | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | MSE Journal Articles |
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