Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes
Howe, Josephine L. C.
Leong, David Tai
Chu, Justin Jang Hann
Loo, Joachim Say Chye
Ng, Kee Woei
Date of Issue2013
School of Materials Science and Engineering
Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.