Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes
Author
Zhao, Yun
Howe, Josephine L. C.
Yu, Zhang
Leong, David Tai
Chu, Justin Jang Hann
Loo, Joachim Say Chye
Ng, Kee Woei
Date of Issue
2013School
School of Materials Science and Engineering
Abstract
Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.
Subject
DRNTU::Engineering::Materials::Nanostructured materials
Type
Journal Article
Series/Journal Title
Small
Rights
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Collections
http://dx.doi.org/10.1002/smll.201201363
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