dc.contributor.authorLuong, Quang Minh
dc.contributor.authorShang, Lei
dc.contributor.authorAng, Marcus
dc.contributor.authorKong, Jen Fong
dc.contributor.authorPeng, Yan
dc.contributor.authorWong, Tina T.
dc.contributor.authorVenkatraman, Subbu S.
dc.date.accessioned2014-04-01T06:54:41Z
dc.date.available2014-04-01T06:54:41Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationLuong, Q. M., Shang, L., Ang, M., Kong, J. F., Peng, Y., Wong, T. T., et al. (2014). A New Design and Application of Bioelastomers for Better Control of Intraocular Pressure in a Glaucoma Drainage Device. Advanced Healthcare Materials, 3(2), 205-213.en_US
dc.identifier.issn2192-2640en_US
dc.identifier.urihttp://hdl.handle.net/10220/19058
dc.description.abstractGlaucoma drainage device (GDD) implantation is an effective method of lowering the intraocular pressure (IOP). Commonly used GDDs can be classified into nonvalved and valved. Although a stable IOP is critical, currently available devices often cause extreme IOP fluctuations: nonvalved GDDs suffer from a risk of hypotony (IOP < 5 mmHg), whereas valved GDDs have a higher risk ocular hypertensive (IOP > 22 mmHg). It is hypothesized that a GDD with a valve designed to open around the time of onset of the hypertensive phase, would minimize IOP fluctuation. Accordingly, a valve fabricated from a biodegradable polymer poly(l -lactide-co -ϵ-caprolactone) (PLC 70/30) is evaluated in vitro and in vivo. The pressure response is compared with its non-degradable counterpart in in vitro studies of IOP. It is also established that in vitro, the biodegradability of the valve is programmed to occur over 12 weeks. In vivo, a steady and low IOP is achieved with the biodegradable valve and the hypertensive phase is significantly attenuated compared with the commercial device. Fibrotic encapsulation of the device is also minimized with the biodegradable valve in vivo.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAdvanced healthcare materialsen_US
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Engineering::Materials
dc.titleA new design and application of bioelastomers for better control of intraocular pressure in a glaucoma drainage deviceen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1002/adhm.201300113


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