dc.contributor.authorLiang, Kun
dc.contributor.authorLi, Xiao Cheng
dc.contributor.authorTay, Beng Kang
dc.identifier.citationLiang, K., Li, X. C., & Tay, B. K. (2013). Study of bone morphogenetic protein-2 delivery with different TiO2 nanotube structures. Nanoscience and Nanotechnology Letters, 5(2), 162-166.en_US
dc.description.abstractA release controlled and localized carrier is important for bone morphogenetic protein delivery in order to enhance the effectiveness in bone repair. In this work, various TiO2 nanotubes with tunable morphologies are fabricated by electrochemical anodization in different organic electrolytes. Their effect on delivery of bone morphogenetic protein-2 (BMP-2) was investigated. During the protein delivery test, it was found that the nanotube structures show superhydrophilic property and tight interaction with protein, compared with the Ti flat surface. The elution profiles of TiO2 nanotube structures have shown slowed down release rate, suppressed initial burst and reduced total amount of BMP-2. The protein retention amount is over 90% for all nanotube structures. The release rate and protein retention are highly related to surface wettability: the more hydrophilic the surface, the slower the release rate and the higher the protein retention. Furthermore, a larger initial burst could be caused by a smaller nanotube density in protein release process.en_US
dc.relation.ispartofseriesNanoscience and nanotechnology lettersen_US
dc.rights© 2013 American Scientific Publishers.en_US
dc.subjectDRNTU::Engineering::Materials::Nanostructured materials
dc.titleStudy of bone morphogenetic protein-2 delivery with different TiO2 nanotube structuresen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US

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