Stereoselective β-C-glycosylation by a palladium-catalyzed decarboxylative allylation : formal synthesis of aspergillide A
Date of Issue2013
School of Physical and Mathematical Sciences
Mild and sweet: The title reaction proceeds under mild conditions with high regio- and diastereoselectivity (see scheme, PG=protecting group, DiPPF=1,1′-bis(diisopropylphosphino)ferrocene). This reaction is suitable for a wide range of glycal-derived γ-ketone esters and affords C-glycosides with exclusive β-selectivity. The method was further applied to a concise formal synthesis of aspergillide A.
DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
Angewandte chemie international edition
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