dc.contributor.authorYang, Yanmei
dc.contributor.authorVelmurugan, Bhaarathy
dc.contributor.authorLiu, Xiaogang
dc.contributor.authorXing, Bengang
dc.date.accessioned2014-04-07T06:03:26Z
dc.date.available2014-04-07T06:03:26Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.citationYang, Y., Velmurugan, B., Liu, X., & Xing, B. (2013). NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release. Small, 9(17), 2937-2944.en_US
dc.identifier.issn1613-6810en_US
dc.identifier.urihttp://hdl.handle.net/10220/19157
dc.description.abstractAn NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of theo-nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light-responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA-conjugated silica-UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR).en_US
dc.language.isoenen_US
dc.relation.ispartofseriesSmallen_US
dc.rights© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Physics
dc.titleNIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug releaseen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/smll.201201765


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