Enantioselective addition of diphenylphosphine to 3-methyl-4-nitro-5-alkenylisoxazoles
Chew, Renta Jonathan
Pullarkat, Sumod A.
Date of Issue2013
School of Physical and Mathematical Sciences
An enantioselective Michael addition reaction of diphenylphosphine to substituted alkenylisoxazoles has been developed. The reaction proceeds efficiently under mild conditions with high yields (up to 99%) and moderate to excellent enantioselectivities (up to 92%) thus providing a hitherto unavailable direct access to a library of chiral tertiary phosphine-functionalized isoxazoles.
Advanced Synthesis & Catalysis
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.