dc.contributor.authorXu, Zhigang
dc.contributor.authorWang, Dongdong
dc.contributor.authorXu, Shuang
dc.contributor.authorLiu, Xiaoyan
dc.contributor.authorZhang, Xiaoyu
dc.contributor.authorZhang, Haixia
dc.identifier.citationXu, Z., Wang, D., Xu, S., Liu, X., Zhang, X., & Zhang, H. (2014). Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery. Chemistry - An Asian Journal, 9(1), 199-205.en_US
dc.description.abstractWe present here a novel camptothecin (CPT) prodrug based on polyethylene glycol monomethyl ether-block-poly(2-methacryl ester hydroxyethyl disulfide-graft-CPT) (MPEG-SS-PCPT). It formed biocompatible nanoparticles (NPs) with diameters of approximately 122 nm with a CPT loading content as high as approximately 25 wt % in aqueous solution. In in vitro release studies, these MPEG-SS-PCPT NPs could undergo triggered disassembly and much faster release of CPT under glutathione (GSH) stimulus than in the absence of GSH. The CPT prodrug had high antitumor activity, and another anticancer drug, doxorubicin hydrochloride (DOX⋅HCl), could also be introduced into the prodrug with a high loading amount. The DOX⋅HCl-loaded CPT prodrug could deliver two anticancer drugs at the same time to produce a collaborative cytotoxicity toward cancer cells, which suggested that this GSH-responsive NP system might become a promising carrier to improve drug-delivery efficacy.en_US
dc.relation.ispartofseriesChemistry - an Asian journalen_US
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Engineering::Chemical engineering::Biochemical engineering
dc.titlePreparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug deliveryen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US

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