Radical-mediated diamination of alkenes with phenylhydrazine and azodicarboxylates : highly diastereoselective synthesis of trans-diamines from cycloalkenes
Date of Issue2013
School of Physical and Mathematical Sciences
Metal-free synthesis: Diamination of alkenes by using phenylhydrazine and azodicarboxylates could be achieved in a one-pot manner under very mild conditions (see scheme; Boc=tert-butoxycarbonyl). This process works with the assistance of acetic acid by means of a radical mechanism and displays a high trans selectivity when cycloalkene substrates were used in the reaction.
Chemistry - a European journal
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