MicroRNAs : the next generation therapeutic targets in human diseases
Selvan, Subramanian Tamil
Date of Issue2013
Lee Kong Chian School of Medicine
MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA- related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/ development.
© 2013 Ivyspring International Publishers. This paper was published in Theranostics and is made available as an electronic reprint (preprint) with permission of Ivyspring International Publishers. The paper can be found at the following official DOI: [http://dx.doi.org/10.7150/thno.7026]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.