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|Title:||Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors||Authors:||Luo, Dahai||Keywords:||DRNTU::Science::Medicine||Issue Date:||2014||Source:||Luo, D. (2014). Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors. RNA Biology, 11(1), 25-32.||Series/Report no.:||RNA biology||Abstract:||The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for signaling initiation, a central RNA helicase core, and a C-terminal domain for RNA sensing. With these specialized sensing-and-responding modules, RLRs are able to selectively bind non-self RNA species and trigger downstream signaling events leading to interferon production. This article summarizes the recent progress toward defining the precise mechanisms of RNA recognition and subsequent signal induction by RLRs.||URI:||https://hdl.handle.net/10356/103313
|ISSN:||1547-6286||DOI:||http://dx.doi.org/10.4161/rna.27717||Rights:||© 2014 Landes Bioscience. This is the author created version of a work that has been peer reviewed and accepted for publication by RNA Biology, Landes Bioscience. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.4161/rna.27717].||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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