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|Title:||Precise control of movement kinematics by optogenetic inhibition of purkinje cell activity||Authors:||Heiney, Shane A.
Augustine, George J.
Medina, Javier F.
|Keywords:||DRNTU::Science::Medicine||Issue Date:||2014||Source:||Heiney, S. A., Kim, J., Augustine, G. J., & Medina, J. F. (2014). Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity. Journal of Neuroscience, 34(6), 2321-2330.||Series/Report no.:||Journal of neuroscience||Abstract:||Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking.Weused an optogenetic approach in awake mice to show for the first time that transiently suppressing spontaneous activity in a population of PCs is sufficient to cause discrete movements that can be systematically modulated in size, speed, and timing depending on how much and how long PC firing is suppressed. We further demonstrate that this fine control of movement kinematics is mediated by a graded disinhibition of target neurons in the deep cerebellar nuclei. Our results prove a long-standing model of cerebellar function and provide the first demonstration that suppression of inhibitory signals can act as a powerful mechanism for the precise control of behavior.||URI:||https://hdl.handle.net/10356/103883
|ISSN:||0270-6474||DOI:||http://dx.doi.org/10.1523/JNEUROSCI.4547-13.2014||Rights:||© 2014 The Authors(s). This paper was published in Journal of Neuroscience and is made available as an electronic reprint (preprint) with permission of Society for Neuroscience. The paper can be found at the following official DOI: http://dx.doi.org/10.1523/JNEUROSCI.4547-13.2014. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.||metadata.item.grantfulltext:||open||metadata.item.fulltext:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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