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Title: Next-generation transgenic mice for optogenetic analysis of neural circuits
Authors: Feng, Guoping
Asrican, Brent
Augustine, George J.
Berglund, Ken
Chen, Susu
Chow, Nick
Gloss, Bernd
Deisseroth, Karl
Mancuso, James
Hira, Riichiro
Hoffmann, Carolin
Tan, Gregory
Kasai, Haruo
Katarya, Malvika
Kim, Jinsook
Kudolo, John
Lee, Li Ming
Lo, Shun Qiang
Matsuzaki, Masanori
Nakajima, Ryuichi
Qiu, Li
Tang, Yanxia
Ting, Jonathan T.
Tsuda, Sachiko
Wen, Lei
Zhang, Xuying
Zhao, Shengli
Keywords: DRNTU::Science::Medicine
Issue Date: 2013
Source: Asrican, B., Augustine, G. J., Berglund, K., Chen, S., Chow, N., Deisseroth, K., et al. (2013). Next-generation transgenic mice for optogenetic analysis of neural circuits. Frontiers in Neural Circuits, 7, 160-.
Series/Report no.: Frontiers in neural circuits
Abstract: Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.
ISSN: 1662-5110
DOI: 10.3389/fncir.2013.00160
Rights: © The Author(s). This paper was published in Frontiers in Neural Circuits and is made available as an electronic reprint (preprint) with permission of Frontiers. The paper can be found at the following official DOI:  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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