dc.contributor.authorLoo, Li Shen
dc.contributor.authorTang, Ning
dc.contributor.authorAl-Haddawi, Muthafar
dc.contributor.authorStewart Dawe, Gavin
dc.contributor.authorHong, Wanjin
dc.date.accessioned2014-05-19T01:48:17Z
dc.date.available2014-05-19T01:48:17Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationLoo, L. S., Tang, N., Al-Haddawi, M., Stewart Dawe, G., & Hong, W. (2014). A role for sorting nexin 27 in AMPA receptor trafficking. Nature Communications, 5, 3176.en_US
dc.identifier.issn2041-1723en_US
dc.identifier.urihttp://hdl.handle.net/10220/19359
dc.description.abstractSorting nexin 27 (SNX27), a PDZ domain-containing endosomal protein, was recently shown to modulate glutamate receptor recycling in Down’s syndrome. However, the precise molecular role of SNX27 in GluA1 trafficking is unclear. Here we report that SNX27 is enriched in dendrites and spines, along with recycling endosomes. Significantly, the mobilization of SNX27 along with recycling endosomes into spines was observed. Mechanistically, SNX27 interacts with K-ras GTPase via the RA domain; and following chemical LTP stimuli, K-ras is recruited to SNX27-enriched endosomes through a Ca2þ/CaM-dependent mechanism, which in turn drives the synaptic delivery of homomeric GluA1 receptors. Impairment of SNX27 prevents LTP and associated trafficking of AMPARs. These results demonstrate a role for SNX27 in neuronal plasticity, provide a molecular explanation for the K-ras signal during LTP and identify SNX27 as the PDZ-containing molecular linker that couples the plasticity stimuli to the delivery of postsynaptic cargo.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)
dc.language.isoenen_US
dc.relation.ispartofseriesNature communicationsen_US
dc.rights© 2014 Macmillan Publishers Limited. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature Communications, Macmillan Publishers Limited. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI:http://dx.doi.org/10.1038/ncomms4176].en_US
dc.subjectDRNTU::Science::Medicine
dc.titleA role for sorting nexin 27 in AMPA receptor traffickingen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicine
dc.identifier.doihttp://dx.doi.org/10.1038/ncomms4176
dc.description.versionAccepted versionen_US


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