Direct β-activation of saturated aldehydes to formal michael acceptors through oxidative NHC catalysis
Chi, Robin Yonggui
Date of Issue2013
School of Physical and Mathematical Sciences
Without detours: Oxidative catalysis mediated by N-heterocyclic carbenes (NHCs) enables the direct β-carbon functionalization of saturated aldehydes (see scheme). The reaction proceeds through two sequential oxidative steps to generate ,β-unsaturated triazolium ester equivalents as formal Michael acceptors, which react with 1,3-diketones and β-ketone esters in an enantioselective manner.
Angewandte chemie international edition
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.