Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
Chi, Robin Yonggui
Date of Issue2012
School of Physical and Mathematical Sciences
A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones.
© 2012 American Chemical Society.