Asymmetric access to the smallest enolate intermediate via organocatalytic activation of acetic ester
Chi, Robin Yonggui
Date of Issue2013
School of Physical and Mathematical Sciences
An NHC-catalyzed activation of acetic esters to afford enolate intermediates is disclosed. The catalytically generated triazolium enolate intermediates serve as two-carbon nucleophiles that undergo highly enantioselective reactions with enones and α,β-unsaturated imines to give α-unsubstituted δ-lactones and lactams, respectively.
© 2013 American Chemical Society.