Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
Chi, Robin Yonggui
Date of Issue2013
School of Physical and Mathematical Sciences
Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported.
© 2013 American Chemical Society