Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/104013
Title: Playing hide and seek : how glycosylation of the influenza virus hemagglutinin can modulate the immune response to infection
Authors: Tate, Michelle D.
Job, Emma R.
Deng, Yi-Mo
Gunalan, Vithiagaran
Maurer-Stroh, Sebastian
Reading, Patrick C.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2014
Source: Tate, M., Job, E., Deng, Y.-M., Gunalan, V., Maurer-Stroh, S., & Reading, P. (2014). Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection. Viruses, 6(3), 1294-1316.
Series/Report no.: Viruses
Abstract: Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including addition of glycans to the hemagglutinin (HA) glycoprotein. The viral HA is the major target recognized by neutralizing antibodies and glycans have been proposed to shield antigenic sites on HA, thereby promoting virus survival in the face of widespread vaccination and/or infection. However, addition of glycans can also interfere with the receptor binding properties of HA and this must be compensated for by additional mutations, creating a fitness barrier to accumulation of glycosylation sites. In addition, glycans on HA are also recognized by phylogenetically ancient lectins of the innate immune system and the benefit provided by evasion of humoral immunity is balanced by attenuation of infection. Therefore, a fine balance must exist regarding the optimal pattern of HA glycosylation to offset competing pressures associated with recognition by innate defenses, evasion of humoral immunity and maintenance of virus fitness. In this review, we examine HA glycosylation patterns of IAV associated with pandemic and seasonal influenza and discuss recent advancements in our understanding of interactions between IAV glycans and components of innate and adaptive immunity.
URI: https://hdl.handle.net/10356/104013
http://hdl.handle.net/10220/19496
ISSN: 1999-4915
DOI: http://dx.doi.org/10.3390/v6031294
Rights: © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

Google ScholarTM

Check

Altmetric

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.