Rhodium-catalyzed C—H alkynylation of arenes at room temperature
Date of Issue2014
School of Physical and Mathematical Sciences
The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.