dc.contributor.authorLi, Huaqiong
dc.contributor.authorWong, Yee Shan
dc.contributor.authorWen, Feng
dc.contributor.authorNg, Kee Woei
dc.contributor.authorNg, Gary Ka Lai
dc.contributor.authorVenkatraman, Subbu S.
dc.contributor.authorBoey, Freddy Yin Chiang
dc.contributor.authorTan, Lay Poh
dc.identifier.citationLi, H., Wong, Y. S., Wen, F., Ng, K. W., Ng, G. K. L., Venkatraman, S. S., et al. (2013). Human Mesenchymal Stem-Cell Behaviour On Direct Laser Micropatterned Electrospun Scaffolds with Hierarchical Structures. Macromolecular Bioscience, 13(3), 299-310.en_US
dc.description.abstractDirect laser machining and electrospinning are utilized to obtain a bi-layered hybrid scaffold with hierarchical topographical features to mimic extracellular matrix-like microenvironment of cells. Adult bone marrow derived human mesenchymal stem cells (hMSCs) are cultured in vitro in these hybrid scaffolds, and cell orientation, proliferation, viability, and differentiation are evaluated. The results show that this novel hybrid scaffold not only supports cell growth like traditional scaffolds, but also elicits positive responses from the cells, like lineage commitment and alignment, which are essential features of future scaffolds.en_US
dc.relation.ispartofseriesMacromolecular bioscienceen_US
dc.rights© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Biological sciences::Molecular biology
dc.titleHuman mesenchymal stem-cell behaviour on direct laser micropatterned electrospun scaffolds with hierarchical structuresen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.organizationA*STAR SIMTechen_US

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