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Title: An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants
Authors: Vigano, Maria Alessandra
Ivanek, Robert
Balwierz, Piotr
Berninger, Philipp
van Nimwegen, Erik
Karjalainen, Klaus
Rolink, Antonius
Keywords: DRNTU::Science::Medicine
Issue Date: 2013
Source: Vigano, M. A., Ivanek, R., Balwierz, P., Berninger, P., van Nimwegen, E., Karjalainen, K., & et al. (2014). An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants. European Journal of Immunology, 44(4), 1181-1193.
Series/Report no.: European journal of immunology
Abstract: Cellular differentiation of the T-cell branch of the immune system begins with the HSC, which undergoes a series of stages characterized by progressive restriction in multipotency and acquisition of specific lineage identity At the molecular level, the restriction of cell potential, commitment, and differentiation to a specific lineage is achieved through the coordinated control of gene expression and epigenetic mechanisms. Here, we analyzed and compared the gene expression profiles and the genome-wide histone modification marks H3K4me3 (H3 lysine 4 trimethylation) and H3K27me3 (H3 lysine 27 trimethylation) in (i) in vitro propagated HSCs, (ii) in vitro generated and propagated pro-T cells derived from these stem cells, and (iii) double-positive thymocytes derived from these pro-T cells after injection into Rag-deficient mice. The combined analyses of the different datasets in this unique experimental system highlighted the importance of both transcriptional and epigenetic repression in shaping the early phases of T-cell development.
ISSN: 0014-2980
DOI: 10.1002/eji.201344022
Rights: © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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