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https://hdl.handle.net/10356/101205
Title: | An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants | Authors: | Vigano, Maria Alessandra Ivanek, Robert Balwierz, Piotr Berninger, Philipp van Nimwegen, Erik Karjalainen, Klaus Rolink, Antonius |
Keywords: | DRNTU::Science::Medicine | Issue Date: | 2013 | Source: | Vigano, M. A., Ivanek, R., Balwierz, P., Berninger, P., van Nimwegen, E., Karjalainen, K., & et al. (2014). An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants. European Journal of Immunology, 44(4), 1181-1193. | Series/Report no.: | European journal of immunology | Abstract: | Cellular differentiation of the T-cell branch of the immune system begins with the HSC, which undergoes a series of stages characterized by progressive restriction in multipotency and acquisition of specific lineage identity At the molecular level, the restriction of cell potential, commitment, and differentiation to a specific lineage is achieved through the coordinated control of gene expression and epigenetic mechanisms. Here, we analyzed and compared the gene expression profiles and the genome-wide histone modification marks H3K4me3 (H3 lysine 4 trimethylation) and H3K27me3 (H3 lysine 27 trimethylation) in (i) in vitro propagated HSCs, (ii) in vitro generated and propagated pro-T cells derived from these stem cells, and (iii) double-positive thymocytes derived from these pro-T cells after injection into Rag-deficient mice. The combined analyses of the different datasets in this unique experimental system highlighted the importance of both transcriptional and epigenetic repression in shaping the early phases of T-cell development. | URI: | https://hdl.handle.net/10356/101205 http://hdl.handle.net/10220/19707 |
ISSN: | 0014-2980 | DOI: | 10.1002/eji.201344022 | Schools: | School of Biological Sciences | Rights: | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SBS Journal Articles |
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