dc.contributor.authorWong, Jiun Ru
dc.contributor.authorShao, Fangwei
dc.date.accessioned2014-06-12T08:09:48Z
dc.date.available2014-06-12T08:09:48Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.citationWong, J. R., & Shao, F. (2014). 8-Cyclopropyl-2′-Deoxyguanosine: A Hole Trap for DNA-Mediated Charge Transport. ChemBioChem, 15(8), 1171-1175.en_US
dc.identifier.issn1439-4227en_US
dc.identifier.urihttp://hdl.handle.net/10220/19711
dc.description.abstractDNA duplexes containing 8-cyclopropyl-2′-deoxyguanosine (8CPG) were synthesized to investigate the effect of the C8-modified deoxyguanosine as a kinetic trap for transient hole occupancy on guanines during DNA-mediated hole transport (HT). Thermal denaturation and CD spectra show that DNA duplexes containing 8CPG are able to form stable B-form duplexes. Photoirradiation of terminal tethered anthraquinone can induce oxidative decomposition of 8CPG through DNA HT along adenine tracts with lengths of up to 4.8 nm. Shallow and periodic distance dependence was observed in a long adenine tract with intervening guanines. The efficient charge transport indicates that 8CPG can electronically couple well with a DNA bridge and form HT-active conformational domains to facilitate transient hole delocalization over an adenine tract.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesChemBioChemen_US
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Science::Biological sciences::Genetics
dc.title8-Cyclopropyl-2′-Deoxyguanosine: a hole trap for DNA-mediated charge transporten_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cbic.201402018


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record