Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines
Date of Issue2014
School of Physical and Mathematical Sciences
A cobalt–N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C[BOND]H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions.
Advanced synthesis & catalysis
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