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|Title:||Ortho-allylation of 1-arylpyrazoles with allyl phenyl ether via iron-catalyzed C-H bond activation under mild conditions||Authors:||Asako, Sobi
|Keywords:||DRNTU::Science::Chemistry||Issue Date:||2014||Source:||Asako, S., Norinder, J., Ilies, L., Yoshikai, N., & Nakamura, E. (2014). ortho -Allylation of 1-Arylpyrazoles with Allyl Phenyl Ether via Iron-Catalyzed C-H Bond Activation under Mild Conditions . Advanced Synthesis & Catalysis, 356(7), 1481-1485.||Series/Report no.:||Advanced synthesis & catalysis||Abstract:||An iron salt and a bipyridine-type ligand catalyze the ortho-allylation of 1-arylpyrazoles and congeners with allyl phenyl ether under mild conditions (0 °C). The ligand, an organozinc base, and the nature of the allylating reagent are crucial for the success of this reaction. Under these conditions, a competitive phenylation reaction is largely retarded, and cross-coupling of the organozinc with the allyl electrophile is minimized. The reaction may proceed via iron-catalyzed ortho C[BOND]H activation to form a metallic intermediate, which then reacts with the allyl ether in a γ selective fashion.||URI:||https://hdl.handle.net/10356/101198
|ISSN:||1615-4150||DOI:||http://dx.doi.org/10.1002/adsc.201400063||Rights:||© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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