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https://hdl.handle.net/10356/101198
Title: | Ortho-allylation of 1-arylpyrazoles with allyl phenyl ether via iron-catalyzed C-H bond activation under mild conditions | Authors: | Asako, Sobi Norinder, Jakob Llies, Laurean Yoshikai, Naohiko Nakamura, Eiichi |
Keywords: | DRNTU::Science::Chemistry | Issue Date: | 2014 | Source: | Asako, S., Norinder, J., Ilies, L., Yoshikai, N., & Nakamura, E. (2014). ortho -Allylation of 1-Arylpyrazoles with Allyl Phenyl Ether via Iron-Catalyzed C-H Bond Activation under Mild Conditions . Advanced Synthesis & Catalysis, 356(7), 1481-1485. | Series/Report no.: | Advanced synthesis & catalysis | Abstract: | An iron salt and a bipyridine-type ligand catalyze the ortho-allylation of 1-arylpyrazoles and congeners with allyl phenyl ether under mild conditions (0 °C). The ligand, an organozinc base, and the nature of the allylating reagent are crucial for the success of this reaction. Under these conditions, a competitive phenylation reaction is largely retarded, and cross-coupling of the organozinc with the allyl electrophile is minimized. The reaction may proceed via iron-catalyzed ortho C[BOND]H activation to form a metallic intermediate, which then reacts with the allyl ether in a γ selective fashion. | URI: | https://hdl.handle.net/10356/101198 http://hdl.handle.net/10220/19715 |
ISSN: | 1615-4150 | DOI: | 10.1002/adsc.201400063 | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SPMS Journal Articles |
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