dc.contributor.authorHe, Liumin
dc.contributor.authorTang, Shuo
dc.contributor.authorPrabhakaran, Molamma P.
dc.contributor.authorLiao, Susan
dc.contributor.authorTian, Lingling
dc.contributor.authorZhang, Yuanming
dc.contributor.authorXue, Wei
dc.contributor.authorRamakrishna, Seeram
dc.identifier.citationHe, L., Tang, S., Prabhakaran, M. P., Liao, S., Tian, L., Zhang, Y., et al. (2013). Surface modification of PLLA nano-scaffolds with laminin multilayer by LbL assembly for enhancing neurite outgrowth. Macromolecular bioscience, 13(11), 1601-1609.en_US
dc.description.abstractIn this study, PLLA nanofibers are fabricated by electrospinning and their surfaces are modified by laminin/chitosan (LN/CS) polyelectrolyte multilayer. Surface C/N ratio determined by XPS analysis quantitatively indicates of discrete coating layers on the nanofibers. The amount of LN deposited sustainably increases with LbL assembly processing, approximately 60 ng mm−2 LN per cycle of LN/CS deposition. The LN-modified PLLA scaffolds significantly induce neurite outgrowth of DRG neurons and NSC compared to the pure PLLA nanofibrous scaffolds. Furthermore, higher amounts of LN adsorbed assist in promoting cell proliferation than PLLA as-spun nanofibers. Therefore, a facile and efficient method to modify nano-scaffolds for the construction of a biomimetic scaffold to promote highly efficient neurite outgrowth is presented.en_US
dc.relation.ispartofseriesMacromolecular bioscienceen_US
dc.rights© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.subjectDRNTU::Engineering::Materials::Nanostructured materials
dc.subjectDRNTU::Science::Medicine::Biomedical engineering
dc.titleSurface modification of PLLA nano-scaffolds with laminin multilayer by LbL assembly for enhancing neurite outgrowthen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US

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