dc.contributor.authorCheow, Wean Sin
dc.contributor.authorXu, Rong
dc.contributor.authorHadinoto, Kunn
dc.date.accessioned2014-06-19T03:48:38Z
dc.date.available2014-06-19T03:48:38Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.citationCheow, W. S., Xu, R., & Hadinoto, K. (2013). Towards Sustainability: New Approaches to Nano-Drug Preparation. Current Pharmaceutical Design, 19(35), 6229-6245.en_US
dc.identifier.issn1381-6128en_US
dc.identifier.urihttp://hdl.handle.net/10220/19825
dc.description.abstractThe conversion of drugs into drug nanoparticles (nano-drugs) represents a feasible method to enhance bioavailability of otherwise sparingly soluble-drugs. Nano-drugs enhance bioavailability through the improvement of dissolution rate and saturation solubility of drugs, by virtue of their small sizes. Nano-drugs available in the market are usually produced by top-down methods, such as wet milling and high pressure homogenization. These conventional top-down methods, however, suffer from high energy and time requirement, as well as wide and inconsistent nano-drug size distribution. Furthermore, commercially available nano-drugs are predominantly crystalline while amorphous nano-drugs are largely neglected despite their propensity to generate high saturation solubility. In this review, nonconventional methods to prepare crystalline and amorphous nano-drugs are discussed, with the bioavailability enhancing characteristics highlighted. Both top-down and bottom-up methods are covered, finally, a sustainability-based perspective comparing amorphous and crystalline nano-drugs is presented.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesCurrent pharmaceutical designen_US
dc.rights© 2013 Bentham Science Publishers.en_US
dc.subjectDRNTU::Engineering::Chemical engineering
dc.titleTowards sustainability : new approaches to nano-drug preparationen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.2174/1381612811319350002


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