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Title: Endoplasmic reticulum stress response in yeast and humans
Authors: Wu, Haoxi
Ng, Benjamin S. H.
Thibault, Guillaume
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2014
Source: Wu, H., Ng, B. S.H., & Thibault, G. (2014). Endoplasmic Reticulum Stress Response in Yeast and Humans. Bioscience Reports, in press.
Series/Report no.: Bioscience reports
Abstract: Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the unfolded protein response (UPR), is an intracellular signal transduction pathway that monitors endoplasmic reticulum (ER) homeostasis. Its activation is required to alleviate the effects of ER stress and is highly conserved from yeast to human. Although metazoans have three UPR outputs, yeast cells rely exclusively on the inositol-requiring enzyme-1 (Ire1) pathway, which is conserved in all Eukaryotes. In general, the UPR program activates hundreds of genes to alleviate ER stress but it can lead to apoptosis if the system fails to restore homeostasis. In this review, we summarize the major advances in understanding the response to ER stress in S. cerevisiae, S. pombe, and humans. The contribution of solved protein structures to a better understanding of the UPR pathway is discussed. Finally, we cover the interplay of ER stress in the development of diseases.
ISSN: 0144-8463
DOI: 10.1042/BSR20140058
Rights: © 2014 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY)( which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

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