Drug-eluting scaffolds for bone and cartilage regeneration
Huang, Charlotte L.
Lee, Wei Li
Loo, Say Chye Joachim
Date of Issue2014
School of Materials Science and Engineering
The advancement in strategies for bone and cartilage regeneration have been centralized on a concept that describes the close relationship between osteogenic cells, osteoconductive scaffolds, delivery growth factors and its mechanical environment. The dynamic nature of tissue repair process involves intricate mimicry of signals expressed in the biological system in response to an injury. Recently, synergistic strategies involving hybrid delivery systems that provide sequential dual delivery of biomolecules and relevant topological cues received great attention. Future advances in tissue regeneration will therefore depend on multidisciplinary strategies that encompass the crux of tissue repair aimed towards constructing the ideal functional regenerative scaffold. Here, functional scaffolds delivering therapeutics are reviewed in terms of their controlled release and healing capabilities.
Drug discovery today
© 2014 Elsevier B.V. This is the author created version of a work that has been peer reviewed and accepted for publication by Drug Discovery Today, Elsevier B.V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1016/j.drudis.2013.11.007.