Thermally modulated photoacoustic imaging with super-paramagnetic iron oxide nanoparticles
Date of Issue2014
School of Electrical and Electronic Engineering
Thermally modulated photoacoustic imaging (TMPI) is reported here for contrast enhancement when using nanoparticles as contrast agents. Exploiting the excellent sensitivity of the photoacoustic (PA) process on temperature and the highly selective heating capability of nanoparticles under electromagnetic field, the PA signals stemming from the nanoparticles labeled region can be efficiently modulated whereas those from highly light absorptive backgrounds are minimally affected. A coherent difference imaging procedure reduces the background signal and thus improves the imaging contrast. Phantom experiments with super-paramagnetic iron oxide nanoparticles (SPIONs) as contrast agents and alternating magnetic fields for heating are demonstrated. Further improvements toward clinical applications are also discussed.
DRNTU::Engineering::Electrical and electronic engineering
© 2014 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The paper can be found at the following official DOI: http://dx.doi.org/10.1364/OL.39.003414. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.